Multi-omics integration reveals the oncogenic role of eccDNAs in diffuse large B-cell lymphoma through STING signalling
Zijuan Wu , Wei Zhang , Luqiao Wang , Jiayan Leng , Yongle Li , Zhou Fan , Mengtao Zhan , Lei Cao , Yongning Jiang , Yan Jiang , Bing Sun , Jianxin Fu , Jianyong Li , Wenyu Shi , Hui Jin
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1815
Multi-omics integration reveals the oncogenic role of eccDNAs in diffuse large B-cell lymphoma through STING signalling
•EccDNAs induced by DNA damage exert an oncogenic role in DLBCL via activating the STING signalling independently of cGAS. | |
•The combined treatment of chemotherapeutic drugs with STING inhibitor significantly delayed the tumor progression, providing new insights into the therapeutic strategy for patients with DLBCL, particularly the relapsed and/or refractory (R/R) ones. |
Diffuse large B-cell lymphoma / DNA damage / EccDNAs / STING signalling
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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