Peripheral immune biomarkers for immune checkpoint inhibition of solid tumours
Meghali Goswami , Nicole J. Toney , Stephanie C. Pitts , Carolina Celades , Jeffrey Schlom , Renee N. Donahue
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1814
Peripheral immune biomarkers for immune checkpoint inhibition of solid tumours
•Peripheral immune biomarkers are critical for improved prediction and prognostication of clinical outcomes for patients with solid tumours treated with immune checkpoint inhibition. | |
•Candidate peripheral biomarkers, such as cytokines, soluble factors, and immune cells, have potential as biomarkers to guide immunotherapy of solid tumours. | |
•Multiple peripheral immune parameters may be integrated to improve prediction and prognostication. | |
•The potential of peripheral immune biomarkers to guide immunotherapy of solid tumours requires critical work in biomarker discovery, validation, and standardization. |
biomarkers / immunotherapy / peripheral blood / tumour microenvironment
Published 2024. This article is a U.S. Government work and is in the public domain in the USA. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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