PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression

Yongxia Chang; Hao Jin; Yun Cui; Feng Yang; Kanghua Chen; Wenjun Kuang; Chunxiao Huo; Zhangqi Xu; Ya Li; Aifu Lin; Bo Yang; Wei Liu; Shanshan Xie; Tianhua Zhou

doi:10.1002/ctm2.1811

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1811 DOI: 10.1002/ctm2.1811

RESEARCH ARTICLE

PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression

Yongxia Chang ¹^,²
, Hao Jin ¹^,²
, Yun Cui ¹^,²
, Feng Yang ³
, Kanghua Chen ²
, Wenjun Kuang ⁴
, Chunxiao Huo ²
, Zhangqi Xu ¹
, Ya Li ¹
, Aifu Lin ⁵
, Bo Yang ⁶^,⁷
, Wei Liu ⁸
, Shanshan Xie ¹^,^†
, Tianhua Zhou ²^,⁹^,^†

Author information +

¹. Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China

². Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

³. Binjiang Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang, China

⁴. International Institutes of Medicine, the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, China

⁵. MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China

⁶. Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

⁷. School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China

⁸. Metabolic Medicine Center, International Institutes of Medicine and the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China

⁹. Zhejiang University Cancer Center, Hangzhou, Zhejiang, China

sxie@zju.edu.cn

tzhou@zju.edu.cn

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Abstract

	•PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis.
	•The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.

Keywords

alkbh3 / gastric cancer / pseudouridylation / pus7

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Yongxia Chang, Hao Jin, Yun Cui, Feng Yang, Kanghua Chen, Wenjun Kuang, Chunxiao Huo, Zhangqi Xu, Ya Li, Aifu Lin, Bo Yang, Wei Liu, Shanshan Xie, Tianhua Zhou. PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression. Clinical and Translational Medicine, 2024, 14(8): e1811 DOI:10.1002/ctm2.1811

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.