Potential pharmaceuticals targeting neuroimmune interactions in treating acute lung injury

Di Wu; Ximing Liao; Jing Gao; Yixuan Gao; Qiang Li; Wei Gao

doi:10.1002/ctm2.1808

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1808 DOI: 10.1002/ctm2.1808

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Potential pharmaceuticals targeting neuroimmune interactions in treating acute lung injury

Di Wu ¹
, Ximing Liao ¹
, Jing Gao ¹
, Yixuan Gao ²^,^†
, Qiang Li ¹^,^†
, Wei Gao ¹^,^†

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Abstract

	•The lungs present abundant nerve innervations.
	•Neuroimmune interactions exert a modulatory effect in the onset and progression of lung inflammatory diseases, especially acute lung injury.
	•The advancements of potential drugs for ALI targeting neuroimmune crosstalk at different stages from preclinical investigation to clinical trials are elaborated.
	•Point out the direction for the development of neuroimmune pharmacology in the future.

Keywords

acute lung injury / airway innervation / inflammation / neuroimmune interaction / potential pharmaceuticals

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Di Wu, Ximing Liao, Jing Gao, Yixuan Gao, Qiang Li, Wei Gao. Potential pharmaceuticals targeting neuroimmune interactions in treating acute lung injury. Clinical and Translational Medicine, 2024, 14(8): e1808 DOI:10.1002/ctm2.1808

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.