Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control

Abstract

	•Pgam5 knockout attenuates alcohol-induced cardiac histopathology and heart dysfunction in male mice.
	•Pgam5 KO reduces alcohol-induced myocardial inflammation, lipid peroxidation and metabolic dysfunction in male mice.
	•Pgam5 depletion protects mitochondrial function in alcohol-exposed male mouse cardiomyocytes.
	•Pgam5 depletion normalises MQC in ACM.
	•EtOH impairs MQC through inducing Phb2 dephosphorylation at Ser91.
	•Pgam5 interacts with Phb2 and induces Phb2 dephosphorylation.
	•Transgenic mice expressing a Ser91 phospho-mimetic Phb2 mutant are resistant to ACM.

Keywords

alcoholic cardiomyopathy / MQC / Pgam5 / Phb2

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