Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control
Jun Tao , Junxiong Qiu , Junmeng Zheng , Ruibing Li , Xing Chang , Qingyong He
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1806
Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control
•Pgam5 knockout attenuates alcohol-induced cardiac histopathology and heart dysfunction in male mice. | |
•Pgam5 KO reduces alcohol-induced myocardial inflammation, lipid peroxidation and metabolic dysfunction in male mice. | |
•Pgam5 depletion protects mitochondrial function in alcohol-exposed male mouse cardiomyocytes. | |
•Pgam5 depletion normalises MQC in ACM. | |
•EtOH impairs MQC through inducing Phb2 dephosphorylation at Ser91. | |
•Pgam5 interacts with Phb2 and induces Phb2 dephosphorylation. | |
•Transgenic mice expressing a Ser91 phospho-mimetic Phb2 mutant are resistant to ACM. |
alcoholic cardiomyopathy / MQC / Pgam5 / Phb2
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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