Metastasis-enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers

Eun-Jung Ahn , Yeong Jin Kim , Md Rashedunnabi Akanda , Se-Jeong Oh , Tae-Young Jung , Shin Jung , Jae-Hyuk Lee , Sung Sun Kim , Yong Yeon Jeong , Hyung-Ho Ha , Hoon Hyun , Hangun Kim , Joon Haeng Rhee , Kyung Keun Kim , Kyung-Hwa Lee , Kyung-Sub Moon

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1804

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1804 DOI: 10.1002/ctm2.1804
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Metastasis-enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers

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Eun-Jung Ahn,Yeong Jin Kim,Md Rashedunnabi Akanda,Se-Jeong Oh,Tae-Young Jung,Shin Jung,Jae-Hyuk Lee,Sung Sun Kim,Yong Yeon Jeong,Hyung-Ho Ha,Hoon Hyun,Hangun Kim,Joon Haeng Rhee,Kyung Keun Kim,Kyung-Hwa Lee,Kyung-Sub Moon. Metastasis-enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers. Clinical and Translational Medicine, 2024, 14(8): e1804 DOI:10.1002/ctm2.1804

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References

[1]

Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997-1003.

[2]

Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012;488(7412):522-526.

[3]

Liu WH, Lin JC, Chou YC, Li MH, Tsai JT. CD44-associated radioresistance of glioblastoma in irradiated brain areas with optimal tumor coverage. Cancer Med. 2020;9(1):350-360.

[4]

Schäfer A, Teufel J, Ringel F, et al. Aldehyde dehydrogenase 1A1—a new mediator of resistance to temozolomide in glioblastoma. Neuro Oncol. 2012;14(12):1452-1464.

[5]

Lee JH, Park SR, Chay KO, et al. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. Cancer Res. 2004;64(12):4235-4243.

[6]

Lee KH, Ahn EJ, Oh SJ, et al. KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers. Oncotarget. 2015;6(5):3240-3253.

[7]

Yang Y, Bae WK, Lee JY, et al. Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer. Sci Rep. 2018;8(1):16234.

[8]

Pal D, Pertot A, Shirole NH, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells. Elife. 2017;6:e21615.

[9]

Meng E, Mitra A, Tripathi K, et al. ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling. PLoS ONE. 2014;9(9):e107142.

[10]

Liu L, Cai S, Han C, et al. ALDH1A1 contributes to PARP inhibitor resistance via enhancing DNA repair in BRCA2(-/-) ovarian cancer cells. Mol Cancer Ther. 2020;19(1):199-210.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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