A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD
Yue Wang , Xinyao Tian , Zhecheng Wang , Deshun Liu , Xuzi Zhao , Xin Sun , Zuoyu Tu , Zekuan Li , Yan Zhao , Shusen Zheng , Jihong Yao
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1801
A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD
•Under normal circumstances, driven by m6A modification, YTHDF2 directly recognizes and degrades circ-SLC9A6, thereby inhibiting the translation of SLC9A6-126aa. | |
•Additionally, AKT1 phosphorylates and inhibits the nuclear translocation of SLC9A6-126aa. | |
•In NAFLD, lipid overload leads to YTHDF2 and AKT1 deficiency, ultimately increasing the expression and nuclear import of SLC9A6-126aa. | |
•Nuclear SLC9A6-126aa binds directly to the CD36 promoter and initiates CD36 transcription, which induces lipid dyshomeostasis. |
circ-RNA translation / h4k16ac / lipid dyshomeostasis / nuclear transport / transcription
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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