Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types

Eunhyong Chang; Su-Jung Kim; Hee Sang Hwang; Kyu Jin Song; Kwoneel Kim; Min-Sik Kim; Se Jin Jang; Sungyong You; Kwang Pyo Kim; Joon-Yong An

doi:10.1002/ctm2.1796

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1796 DOI: 10.1002/ctm2.1796

LETTER TO THE JOURNAL

Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types

Eunhyong Chang ¹^,²
, Su-Jung Kim ³
, Hee Sang Hwang ⁴
, Kyu Jin Song ³^,⁵
, Kwoneel Kim ⁶^,⁷
, Min-Sik Kim ⁸^,⁹^,¹⁰
, Se Jin Jang ⁴^,¹¹
, Sungyong You ¹²^,¹³
, Kwang Pyo Kim ³^,⁵^,^†
, Joon-Yong An ¹^,²^,¹⁴^,^†

Author information +

¹. Department of Integrated Biomedical and Life Science, Korea University, Seoul, Republic of Korea

². L-HOPE Program for Community-Based Total Learning Health Systems, Korea University, Seoul, Republic of Korea

³. Department of Applied Chemistry, Institute of Natural Science, Kyung Hee University, Yongin, Republic of Korea

⁴. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea

⁵. Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea

⁶. Department of Biology, Kyung Hee University, Seoul, Republic of Korea

⁷. Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea

⁸. Department of New Biology, DGIST, Daegu, Republic of Korea

⁹. New Biology Research Center, DGIST, Daegu, Republic of Korea

¹⁰. Center for Cell Fate Reprogramming and Control, DGIST, Daegu, Republic of Korea

¹¹. SG Medical, Inc., Seoul, Republic of Korea

¹². Department of Urology, Cedars-Sinai Medical Center, Los Angeles, California, USA

¹³. Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California, USA

¹⁴. School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea

kimkp@khu.ac.kr

joonan30@korea.ac.kr

Show less

History +

PDF

Cite this article

Download citation ▾

Eunhyong Chang, Su-Jung Kim, Hee Sang Hwang, Kyu Jin Song, Kwoneel Kim, Min-Sik Kim, Se Jin Jang, Sungyong You, Kwang Pyo Kim, Joon-Yong An. Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer types. Clinical and Translational Medicine, 2024, 14(8): e1796 DOI:10.1002/ctm2.1796

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Bielski CM, Zehir A, Penson AV, et al. Genome doubling shapes the evolution and prognosis of advanced cancers. Nat Genet. 2018;50(8):1189-1195.

[2]	Quinton RJ, DiDomizio A, Vittoria MA, et al. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021;590(7846):492-497.

[3]	Li Y, Dou Y, Da Veiga Leprevost F, et al. Proteogenomic data and resources for pan-cancer analysis. Cancer Cell. 2023;41(8):1397-1406.

[4]	Steele CD, Abbasi A, Islam SMA, et al. Signatures of copy number alterations in human cancer. Nature. 2022;606(7916):984-991.

[5]	Chalmers ZR, Connelly CF, Fabrizio D, et al. Analysis of 100, 000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 2017;9(1):34.

[6]	Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017;355(6322):eaaf8399.

[7]	Zeng J, Hills SA, Ozono E, Diffley JFX. Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication. Cell. 2023;186(3):528-542. e14.

[8]	Korinek V, Barker N, Morin PJ, et al. Constitutive transcriptional activation by a β-catenin–Tcf complex in APC^−/− colon carcinoma. Science. 1997;275(5307):1784-1787.

[9]	Xie X, Yu T, Li X, et al. Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials. Signal Transduct Target Ther. 2023;8(1):335.

RIGHTS & PERMISSIONS

2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.