The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

Abstract

	•IGF2BP3 deficiency inactivates Jag1 signalling.
	•IGF2BP3 deficiency-mediated m6A modifications promote HSC ferroptosis.
	•IGF2BP3 inhibition facilitates ferroptosis in HSCs via the Hes1/GPX4 axis.
	•IGF2BP3 deficiency inactivates Jag1/Notch1/3/Hes1 signalling pathway inactivation, leading to the decrease in GPX4, which contributes to HSC ferroptosis.

Keywords

ferroptosis / IGF2BP3 deficiency / liver fibrosis / m ⁶A methyltransferase

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.