The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

Xinmiao Li; Yifei Li; Weizhi Zhang; Feng Jiang; Lifan Lin; Yining Wang; Lingling Wu; Han Zeng; Jianjian Zheng

doi:10.1002/ctm2.1793

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1793 DOI: 10.1002/ctm2.1793

RESEARCH ARTICLE

The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis

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Abstract

	•IGF2BP3 deficiency inactivates Jag1 signalling.
	•IGF2BP3 deficiency-mediated m⁶A modifications promote HSC ferroptosis.
	•IGF2BP3 inhibition facilitates ferroptosis in HSCs via the Hes1/GPX4 axis.
	•IGF2BP3 deficiency inactivates Jag1/Notch1/3/Hes1 signalling pathway inactivation, leading to the decrease in GPX4, which contributes to HSC ferroptosis.

Keywords

ferroptosis / IGF2BP3 deficiency / liver fibrosis / m ⁶A methyltransferase

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Xinmiao Li, Yifei Li, Weizhi Zhang, Feng Jiang, Lifan Lin, Yining Wang, Lingling Wu, Han Zeng, Jianjian Zheng. The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis. Clinical and Translational Medicine, 2024, 14(8): e1793 DOI:10.1002/ctm2.1793

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.