Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage

Abstract

	•Eif5 deletion in oocytes leads to arrest in oocyte growth and follicle development.
	•Eif5 deletion in oocytes impairs the translation of mitochondrial fission-related proteins, followed by mitochondrial dysfunction.
	•Depletion of Eif5 causes oocyte apoptosis via ROS accumulation and DNA damage response pathway.

Keywords

eIF5 / follicle development / mitochondrial fission / oocyte growth / POI

References

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.