Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage

Weiyong Wang; Huiyu Liu; Shuang Liu; Tiantian Hao; Ying Wei; Hongwei Wei; Wenjun Zhou; Xiaodan Zhang; Xiaoqiong Hao; Meijia Zhang

doi:10.1002/ctm2.1791

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1791 DOI: 10.1002/ctm2.1791

RESEARCH ARTICLE

Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage

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Abstract

	•Eif5 deletion in oocytes leads to arrest in oocyte growth and follicle development.
	•Eif5 deletion in oocytes impairs the translation of mitochondrial fission-related proteins, followed by mitochondrial dysfunction.
	•Depletion of Eif5 causes oocyte apoptosis via ROS accumulation and DNA damage response pathway.

Keywords

eIF5 / follicle development / mitochondrial fission / oocyte growth / POI

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Weiyong Wang,Huiyu Liu,Shuang Liu,Tiantian Hao,Ying Wei,Hongwei Wei,Wenjun Zhou,Xiaodan Zhang,Xiaoqiong Hao,Meijia Zhang. Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage. Clinical and Translational Medicine, 2024, 14(8): e1791 DOI:10.1002/ctm2.1791

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.