Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage
Weiyong Wang , Huiyu Liu , Shuang Liu , Tiantian Hao , Ying Wei , Hongwei Wei , Wenjun Zhou , Xiaodan Zhang , Xiaoqiong Hao , Meijia Zhang
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1791
Oocyte-specific deletion of eukaryotic translation initiation factor 5 causes apoptosis of mouse oocytes within the early-growing follicles by mitochondrial fission defect-reactive oxygen species-DNA damage
•Eif5 deletion in oocytes leads to arrest in oocyte growth and follicle development. | |
•Eif5 deletion in oocytes impairs the translation of mitochondrial fission-related proteins, followed by mitochondrial dysfunction. | |
•Depletion of Eif5 causes oocyte apoptosis via ROS accumulation and DNA damage response pathway. |
eIF5 / follicle development / mitochondrial fission / oocyte growth / POI
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
/
| 〈 |
|
〉 |