Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling

Jinfu Qian; Qinyan Wang; Jiachen Xu; Shiqi Liang; Qingsong Zheng; Xiaocheng Guo; Wu Luo; Weijian Huang; Xiaohong Long; Julian Min; Yi Wang; Gaojun Wu; Guang Liang

doi:10.1002/ctm2.1790

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1790 DOI: 10.1002/ctm2.1790

RESEARCH ARTICLE

Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling

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Abstract

	•Macrophage CARD9 was elevated in heart tissues of mice under chronic ISO administration.
	•Either whole-body CARD9 knockout or myeloid-specific CARD9 deficiency protected mice from ISO-induced inflammatory heart remodeling.
	•ISO promoted the assembly of CBM complex and then activated NF-κB signaling in macrophages through OTUD1-mediated deubiquitinating modification.
	•OTUD1 deletion in myeloid cells protected hearts from ISO-induced injuries in mice.

Keywords

CARD9 / heart failure / inflammation / isoproterenol / macrophage / OTUD1

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Jinfu Qian,Qinyan Wang,Jiachen Xu,Shiqi Liang,Qingsong Zheng,Xiaocheng Guo,Wu Luo,Weijian Huang,Xiaohong Long,Julian Min,Yi Wang,Gaojun Wu,Guang Liang. Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling. Clinical and Translational Medicine, 2024, 14(8): e1790 DOI:10.1002/ctm2.1790

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.