Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Jiaqiang Xiong; Lu Dong; Qiongying Lv; Yutong Yin; Jiahui Zhao; Youning Ke; Shixuan Wang; Wei Zhang; Meng Wu

doi:10.1002/ctm2.1772

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e1772 DOI: 10.1002/ctm2.1772

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Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

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Abstract

	•Senescence-associated secretory phenotype (SASP) secretion from senescent tumour cells significantly impacts cancer progression and biology.
	•SASP is involved in regulating the remodelling of the tumour microenvironment, including immune microenvironment, vascular, extracellular matrix and cancer stem cells.
	•Senotherapeutics, such as senolytic, senomorphic, nanotherapy and senolytic vaccines, hold promise for enhancing cancer treatment efficacy.

Keywords

cell senescence / SASP / senolytic / tumour microenvironment

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Jiaqiang Xiong,Lu Dong,Qiongying Lv,Yutong Yin,Jiahui Zhao,Youning Ke,Shixuan Wang,Wei Zhang,Meng Wu. Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes. Clinical and Translational Medicine, 2024, 14(9): e1772 DOI:10.1002/ctm2.1772

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.