Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation

Peng Chen; Zhentao Zhang; Lilian Sakai; Yanping Xu; Shanzhi Wang; Kyung Eun Lee; Bingchuan Geng; Jongsoo Kim; Bao Zhao; Qiang Wang; Haitao Wen; Heather L. Chandler; Hua Zhu

doi:10.1002/ctm2.1762

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e1762 DOI: 10.1002/ctm2.1762

RESEARCH ARTICLE

Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation

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Abstract

	•Neutrophil pyroptosis delays re-epithelialization after corneal injury
	•Compromised re-epithelialization promotes corneal neovascularization afterinjury
	•Inhibition of post-injury pyroptosis could be an effective therapy to promote corneal wound healing.

Keywords

corneal wound healing / neovascularisation / neutrophil / pyroptosis

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Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Shanzhi Wang, Kyung Eun Lee, Bingchuan Geng, Jongsoo Kim, Bao Zhao, Qiang Wang, Haitao Wen, Heather L. Chandler, Hua Zhu. Neutrophil pyroptosis regulates corneal wound healing and post-injury neovascularisation. Clinical and Translational Medicine, 2024, 14(11): e1762 DOI:10.1002/ctm2.1762

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.