B-cell performance in chemotherapy: Unravelling the mystery of B-cell therapeutic potential
Zizhuo Li , Anqi Lin , Zhifei Gao , Aimin Jiang , Minying Xiong , Jiapeng Song , Zaoqu Liu , Quan Cheng , Jian Zhang , Peng Luo
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (7) : e1761
B-cell performance in chemotherapy: Unravelling the mystery of B-cell therapeutic potential
• Chemotherapy can inhibit B-cell proliferation and alter subset distributions and functions, including factor secretion, receptor signalling, and costimulation. • Chemotherapy can modulate complex B-cell–T-cell interactions with variable effects on anti-tumour immunity • Targeting B-cell surface markers or signalling improves chemotherapy responses, blocks immune evasion and inhibits tumour growth. • Critical knowledge gaps remain regarding B-cell interactions in TME, B-cell chemoresistance mechanisms, TLS biology, heterogeneity, spatial distributions, chemotherapy drug selection and B-cell targets that future studies should address.
anti-tumour therapy / B cells / chemotherapy / neoadjuvant chemotherapy (NACT) / targeting B cells / tumour microenvironment (TME)
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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