A hidden proteome encoded by circRNAs in human placentas: Implications for uncovering preeclampsia pathogenesis

Abstract

• A hidden circRNA-encoded proteome in the human placenta was extensively identified and systematically characterised.

• The circRNA-encoded proteins (CEPs) are potentially related to placental development and associated disorders.

• A novel conserved CEP circPRKCB119aa enhanced trophoblast autophagy by inhibiting phosphorylation of its cognate linear-spliced isoform protein kinase C (PKC) β in preeclampsia.

Keywords

circRNA-encoded protein / circular RNA / placenta / preeclampsia

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.