ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer

Yiding Wang; Xuejun Gan; Xiaojing Cheng; Yongning Jia; Gangjian Wang; Xiaohuan Tang; Hong Du; Xiaomei Li; Xijuan Liu; Xiaofang Xing; Jiafu Ji; Ziyu Li

doi:10.1002/ctm2.1754

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (8) : e1754 DOI: 10.1002/ctm2.1754

RESEARCH ARTICLE

ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer

Yiding Wang ¹^,²
, Xuejun Gan ¹^,²
, Xiaojing Cheng ¹
, Yongning Jia ²
, Gangjian Wang ¹^,²
, Xiaohuan Tang ¹^,²
, Hong Du ¹
, Xiaomei Li ¹
, Xijuan Liu ³
, Xiaofang Xing ¹^,^†
, Jiafu Ji ¹^,²^,^†
, Ziyu Li ¹^,²^,^†

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Abstract

	•ABCC2 plays a crucial role in inducing metabolic vulnerability and ferroptosis in gastric cancer through enhanced glutathione efflux.
	•The ABCC2 24C > T polymorphism is a key factor influencing its expression.
	•These results highlight the potential of ABCC2 as a predictive biomarker and therapeutic target in gastric cancer.

Keywords

ABCC2 / amino acid metabolism / ferroptosis / gastric cancer / glutathione

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Yiding Wang, Xuejun Gan, Xiaojing Cheng, Yongning Jia, Gangjian Wang, Xiaohuan Tang, Hong Du, Xiaomei Li, Xijuan Liu, Xiaofang Xing, Jiafu Ji, Ziyu Li. ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer. Clinical and Translational Medicine, 2024, 14(8): e1754 DOI:10.1002/ctm2.1754

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.