Single-cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy
Xinzi Zhang , Fang Zhang , Xun Xu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (7) : e1751
Single-cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy
• Progress in scRNA-seq for diabetic retinopathy (DR) research includes studies on DR patients, non-human primates, and the prevalent mouse models. • scRNA-seq facilitates the identification of differentially expressed genes, pivotal cell subpopulations, and complex cell-cell interactions in DR at single-cell level. • Future scRNA-seq applications in DR should target specific patient subsets and integrate with single-cell and spatial multi-omics approaches.
diabetic retinopathy / pathogenesis / single-cell RNA sequencing
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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