Single-cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy

Abstract

• Progress in scRNA-seq for diabetic retinopathy (DR) research includes studies on DR patients, non-human primates, and the prevalent mouse models.

• scRNA-seq facilitates the identification of differentially expressed genes, pivotal cell subpopulations, and complex cell-cell interactions in DR at single-cell level.

• Future scRNA-seq applications in DR should target specific patient subsets and integrate with single-cell and spatial multi-omics approaches.

Keywords

diabetic retinopathy / pathogenesis / single-cell RNA sequencing

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