Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities

Lulu Chen; Shuting Huang; Xiaoxue Wu; Weiling He; Mei Song

doi:10.1002/ctm2.1750

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (7) : e1750 DOI: 10.1002/ctm2.1750

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Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities

Lulu Chen ¹^,²
, Shuting Huang ³
, Xiaoxue Wu ¹
, Weiling He ¹^,⁴^,^†
, Mei Song ²^,^†

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Abstract

• Primary synthesis and metabolic routes of peripheral 5-hydroxytryptamine in the gastrointestinal tract.

• Advanced research has established a strong association between the serotonergic components and carcinogenic mechanisms.

• The interplay between serotonergic signalling and the immune system within the tumour microenvironment orchestrates antitumour immune responses.

• Serotonergic-targeted drugs offer valuable clinical options for cancer therapy

Keywords

immunomodulatory function / serotonergic drugs / serotonin / serotonylation / tumourigenesis

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Lulu Chen, Shuting Huang, Xiaoxue Wu, Weiling He, Mei Song. Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities. Clinical and Translational Medicine, 2024, 14(7): e1750 DOI:10.1002/ctm2.1750

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.