Inhibiting the cGAS-STING pathway in myeloid cells effectively improves myocardial healing related to TET2 deficiency-induced DNA damage response
Yaling Dou , Yan Zhang , Logan Rivera , Tingting Hong , Shaohai Fang , Thuy Tien Tran , Yubin Zhou , James F. Martin , Yun Huang
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1741
Inhibiting the cGAS-STING pathway in myeloid cells effectively improves myocardial healing related to TET2 deficiency-induced DNA damage response
Myeloid-specific Tet2 depletion promotes neutrophil expansion upon myocardium infarction (MI); Tet2-deficient myeloid cells exhibit increased genome instability and cGASSTING overactivation; STING antagonist H-151 treatment reduces neutrophil expansion in Tet2- deficient mice after MI and mitigates deleterious cardiac outcomes.
cGAS-STING / epigenetics / myocardial repair / TET2
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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