KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma

Abstract

Single-cell RNA-sequencing reveals a transcriptome catalogue comparing sporadic parathyroid adenomas (PAs) with normal parathyroid glands.

PA cells show a pervasive increase in gene expression linked to KMT2A upregulation.

KMT2A-mediated STAT3 and GATA3 upregulation is key to promoting PA cell proliferation via cyclin D2.

PAs exhibit a proinflammatory microenvironment, suggesting a potential role of chronic inflammation in PA pathogenesis.

Keywords

CCND2 / cyclin D2 / epigenetics / KMT2A / single-cell analysis / sporadic parathyroid adenoma

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.