KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma

Qin Xu; Ting La; Kaihong Ye; Li Wang; Shasha Wang; Yifeng Hu; Liu Teng; Lei Yan; Jinming Li; Zhenhua Zhang; Zehua Shao; Yuan Yuan Zhang; Xiao Hong Zhao; Yu Chen Feng; Lei Jin; Mark Baker; Rick F. Thorne; Xu Dong Zhang; Feng-Min Shao; Huixia Cao

doi:10.1002/ctm2.1734

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1734 DOI: 10.1002/ctm2.1734

RESEARCH ARTICLE

KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma

Author information +

¹. Department of Nephrology, Henan Key Laboratory of Kidney Disease and Immunology of Zhengzhou University People's Hospital, Zhengzhou University People's Hospital ,Henan Provincial People's Hospital, Zhengzhou, China

². National-Local Joint Engineering Research Center of Biodiagnosis & Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China

³. Translational Research Institute, Henan Provincial and Zhengzhou City Key Laboratory of Non-Coding RNA and Cancer Metabolism, Henan International Join Laboratory of Non-Coding RNA and Metabolism in Cancer, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China

⁴. School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China

⁵. Department of Nephrology, Xinxiang Medical University, Xinxiang, China

⁶. Department of Thyroid Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China

⁷. Children's Heart Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China

⁸. School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia

⁹. School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia

Xu.Zhang@newcastle.edu.au

fengminshao@126.com

huixiacao310@126.com

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Abstract

Single-cell RNA-sequencing reveals a transcriptome catalogue comparing sporadic parathyroid adenomas (PAs) with normal parathyroid glands.

PA cells show a pervasive increase in gene expression linked to KMT2A upregulation.

KMT2A-mediated STAT3 and GATA3 upregulation is key to promoting PA cell proliferation via cyclin D2.

PAs exhibit a proinflammatory microenvironment, suggesting a potential role of chronic inflammation in PA pathogenesis.

Keywords

CCND2 / cyclin D2 / epigenetics / KMT2A / single-cell analysis / sporadic parathyroid adenoma

Cite this article

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Qin Xu,Ting La,Kaihong Ye,Li Wang,Shasha Wang,Yifeng Hu,Liu Teng,Lei Yan,Jinming Li,Zhenhua Zhang,Zehua Shao,Yuan Yuan Zhang,Xiao Hong Zhao,Yu Chen Feng,Lei Jin,Mark Baker,Rick F. Thorne,Xu Dong Zhang,Feng-Min Shao,Huixia Cao. KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma. Clinical and Translational Medicine, 2024, 14(6): e1734 DOI:10.1002/ctm2.1734

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.