Heavy metals in cigarette smoke strongly inhibit pancreatic ductal function and promote development of chronic pancreatitis

Petra Pallagi; Emese Tóth; Marietta Görög; Viktória Venglovecz; Tamara Madácsy; Árpád Varga; Tünde Molnár; Noémi Papp; Viktória Szabó; Enikő Kúthy-Sutus; Réka Molnár; Attila Ördög; Katalin Borka; Andrea Schnúr; Albert Kéri; Gyula Kajner; Kata Csekő; Emese Ritter; Dezső Csupor; Zsuzsanna Helyes; Gábor Galbács; Andrea Szentesi; László Czakó; Zoltán Rakonczay; Tamás Takács; József Maléth; Péter Hegyi

doi:10.1002/ctm2.1733

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1733 DOI: 10.1002/ctm2.1733

RESEARCH ARTICLE

Heavy metals in cigarette smoke strongly inhibit pancreatic ductal function and promote development of chronic pancreatitis

Author information +

¹. Department of Medicine, University of Szeged, Szeged, Hungary

². MTA–SZTE Momentum Epithelial Cell Signaling and Secretion Research Group, University of Szeged, Szeged, Hungary

³. HCEMM–SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary

⁴. Department of Theoretical and Integrative Health Sciences, University of Debrecen, Szeged, Hungary

⁵. Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary

⁶. Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary

⁷. Department of Plant Biology, University of Szeged, Szeged, Hungary

⁸. Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary

⁹. Department of Molecular and Analytical Chemistry, University of Szeged, Szeged, Hungary

¹⁰. Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary

¹¹. National Laboratory of Drug Research and Development (Pharmalab), Budapest, Hungary

¹². Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary

¹³. Institute of Clinical Pharmacy, University of Szeged, Szeged, Hungary

¹⁴. Institute for Translational Medicine, University of Pécs, Pécs, Hungary

¹⁵. Eötvös Loránd Research Network Chronic Pain Research Group, University of Pécs, Pécs, Hungary

¹⁶. Department of Pathophysiology, University of Szeged, Szeged, Hungary

¹⁷. Center of Translational Medicine and Institute of Pancreatic Disorders, Semmelweis University, Budapest, Hungary

hegyi.peter@semmelweis-univ.hu

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Abstract

Smoking and cigarette smoke extract diminish pancreatic ductal fluid and HCO₃ ^– secretion as well as the expression and function of CFTR

Cd and Hg concentrations are significantly higher in the serum samples of smokers

Cd accumulates in the pancreatic tissue of smokers

Keywords

cadmium / CFTR / chronic pancreatitis / epithelial ion secretion / smoking

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Petra Pallagi, Emese Tóth, Marietta Görög, Viktória Venglovecz, Tamara Madácsy, Árpád Varga, Tünde Molnár, Noémi Papp, Viktória Szabó, Enikő Kúthy-Sutus, Réka Molnár, Attila Ördög, Katalin Borka, Andrea Schnúr, Albert Kéri, Gyula Kajner, Kata Csekő, Emese Ritter, Dezső Csupor, Zsuzsanna Helyes, Gábor Galbács, Andrea Szentesi, László Czakó, Zoltán Rakonczay, Tamás Takács, József Maléth, Péter Hegyi. Heavy metals in cigarette smoke strongly inhibit pancreatic ductal function and promote development of chronic pancreatitis. Clinical and Translational Medicine, 2024, 14(6): e1733 DOI:10.1002/ctm2.1733

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.