Impact of ALK inhibitors to potentiate ALK.CAR-T therapy in neuroblastoma

Elisa Bergaggio , Roberto Chiarle

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1732

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1732 DOI: 10.1002/ctm2.1732
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Impact of ALK inhibitors to potentiate ALK.CAR-T therapy in neuroblastoma

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Elisa Bergaggio, Roberto Chiarle. Impact of ALK inhibitors to potentiate ALK.CAR-T therapy in neuroblastoma. Clinical and Translational Medicine, 2024, 14(6): e1732 DOI:10.1002/ctm2.1732

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Del Bufalo F, De Angelis B, Caruana I, et al. GD2-CART01 for relapsed or refractory high-risk neuroblastoma. N Engl J Med. 2023;388:1284-1295.

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Sano R, Krytska K, Larmour CE, et al. An antibody–drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma. Sci Transl Med. 2019;11(483):eaau9732.

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Bergaggio E, Tai W-T, Aroldi A, et al. ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells. Cancer Cell. 2023;41(12):2100-2116.e10.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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