Single-cell and spatial alterations of neural cells and circuits in clinical and translational medicine

William Wang , Xuanqi Liu , Diane Catherine Wang

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1696

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (6) : e1696 DOI: 10.1002/ctm2.1696
EDITORIAL

Single-cell and spatial alterations of neural cells and circuits in clinical and translational medicine

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Abstract

The spatiotemporal heterogeneity of neurons, circuits and regulators is being uncovered at a single-cell level, from single-cell gene expression to functional regulations. The classifications, architectonics and functional communications amongst neural cells and circuits within the brain can be clearly delineated using single-cell multiomics and transomics. This Editorial highlights the spatiotemporal heterogeneity of neurons and circuits as well as regulators, initiates the translation of neuronal diversity and spatial organisation at single-cell levels into clinical considerations, and enables the discovery and development of new therapies for neurological diseases. It is predicted that single-cell and spatial multiomics will be integrated with metabolomic profiles and corresponding gene epigenetic modifications. The interactions amongst DNAs, RNAs and proteins in a cell provide details of intracellular functional regulations and new opportunities for the translation of temporospatial diversity of neural cell subtypes/states into clinical practice. The application of single-cell multiomics with four-dimensional genome to the human pathological brain will lead us to a new milestone of the diagnosis and treatment.

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clinical / disease / medicine / single-cell / translational

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William Wang, Xuanqi Liu, Diane Catherine Wang. Single-cell and spatial alterations of neural cells and circuits in clinical and translational medicine. Clinical and Translational Medicine, 2024, 14(6): e1696 DOI:10.1002/ctm2.1696

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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