Synergistic inhibition of progesterone receptor-A/B signalling by simvastatin and mifepristone in human uterine leiomyomas

Sadia Afrin; Gregory W. Kirschen; Mariko Miyashita-Ishiwata; Malak El Sabeh; Mostafa A. Borahay

doi:10.1002/ctm2.1672

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1672 DOI: 10.1002/ctm2.1672

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Synergistic inhibition of progesterone receptor-A/B signalling by simvastatin and mifepristone in human uterine leiomyomas

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Sadia Afrin, Gregory W. Kirschen, Mariko Miyashita-Ishiwata, Malak El Sabeh, Mostafa A. Borahay. Synergistic inhibition of progesterone receptor-A/B signalling by simvastatin and mifepristone in human uterine leiomyomas. Clinical and Translational Medicine, 2024, 14(4): e1672 DOI:10.1002/ctm2.1672

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References

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[2]	Enazy SAl, Kirschen GW, Vincent K, et al. PEGylated polymeric nanoparticles loaded with 2-methoxyestradiol for the treatment of uterine leiomyoma in a patient-derived xenograft mouse model. J Pharm Sci. 2023;112(9):2552-2560.

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[6]	Bulun SE, Moravek MB, Yin P, et al. Uterine leiomyoma stem cells: linking progesterone to growth. Semin Reprod Med. 2015;33(5):357-365.

[7]	Borahay MA, Vincent K, Motamedi M, et al. Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study. Am J Obstet Gynecol. 2015;213(2):196.e1-e8

[8]	Afrin S, El Sabeh M, Islam MS, et al. Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. Pharmacol Res. 2021;172:105856.

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.