ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion

Abstract

• ACOD1 attenuated neuroinflammation and oxidative stress after spinal cord injury.

• ACOD1, not itaconate, interacted with p-p62 to facilitate Nrf2 expression and nuclear translocation.

• Nrf2 was capable of promoting ACOD1 transcription in microglia.

Keywords

aconitate decarboxylase 1 / itaconate / neuroinflammation / Nrf2 / p62 / spinal cord injury

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.