ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion

Zhanyang Qian; Mingjie Xia; Tianyu Zhao; You Li; Guangshen Li; Yanan Zhang; Haijun Li; Lei Yang

doi:10.1002/ctm2.1661

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1661 DOI: 10.1002/ctm2.1661

RESEARCH ARTICLE

ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion

Zhanyang Qian ¹^,^†
, Mingjie Xia ²
, Tianyu Zhao ¹^,³
, You Li ⁴
, Guangshen Li ¹
, Yanan Zhang ¹^,³
, Haijun Li ¹^,^†
, Lei Yang ¹^,^†

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Abstract

• ACOD1 attenuated neuroinflammation and oxidative stress after spinal cord injury.

• ACOD1, not itaconate, interacted with p-p62 to facilitate Nrf2 expression and nuclear translocation.

• Nrf2 was capable of promoting ACOD1 transcription in microglia.

Keywords

aconitate decarboxylase 1 / itaconate / neuroinflammation / Nrf2 / p62 / spinal cord injury

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Zhanyang Qian, Mingjie Xia, Tianyu Zhao, You Li, Guangshen Li, Yanan Zhang, Haijun Li, Lei Yang. ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion. Clinical and Translational Medicine, 2024, 14(4): e1661 DOI:10.1002/ctm2.1661

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.