Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy

Jie Mei; Xingjian Liu; Hui-Xiang Tian; Yixuan Chen; Yang Cao; Jun Zeng; Yung-Chiang Liu; Yaping Chen; Yang Gao; Ji-Ye Yin; Peng-Yuan Wang

doi:10.1002/ctm2.1656

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1656 DOI: 10.1002/ctm2.1656

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Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy

Jie Mei ¹^,²^,³^,⁴^,⁵
, Xingjian Liu ¹
, Hui-Xiang Tian ²^,³
, Yixuan Chen ¹
, Yang Cao ¹
, Jun Zeng ¹^,⁶
, Yung-Chiang Liu ¹
, Yaping Chen ¹
, Yang Gao ⁵^,⁶^,⁷^,⁸^,^†
, Ji-Ye Yin ²^,³^,⁴^,⁵^,^†
, Peng-Yuan Wang ¹^,^†

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Abstract

• The current PDTO models have not yet constructed key cellular and noncellular components.

• PDTOs should be expandable and editable.

• PDTOs are promising preclinical models for immunotherapy unless mature PDTOs can be established.

• PDTO biobanks with consensual standards are urgently

Keywords

organoid / assembloid / cell therapy / immunotherapy / PDTO biobank

Cite this article

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Jie Mei,Xingjian Liu,Hui-Xiang Tian,Yixuan Chen,Yang Cao,Jun Zeng,Yung-Chiang Liu,Yaping Chen,Yang Gao,Ji-Ye Yin,Peng-Yuan Wang. Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy. Clinical and Translational Medicine, 2024, 14(4): e1656 DOI:10.1002/ctm2.1656

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.