ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke

Jonathan Z. Pan; Zhanqiang Wang; Wei Sun; Peipei Pan; Wei Li; Yongtao Sun; Shoulin Chen; Amity Lin; Wulin Tan; Liangliang He; Jacob Greene; Virginia Yao; Lijun An; Rich Liang; Qifeng Li; Jessica Yu; Lingyi Zhang; Nikolaos Kyritsis; Xuan Duong Fernandez; Sara Moncivais; Esmeralda Mendoza; Pamela Fung; Gongming Wang; Xinhuan Niu; Qihang Du; Zhaoyang Xiao; Yuwen Chang; Peiyuan Lv; J. Russell Huie; Abel Torres-Espin; Adam R. Ferguson; Debra D. Hemmerle; Jason F. Talbott; Philip R. Weinstein; Lisa U. Pascual; Vineeta Singh; Anthony M. DiGiorgio; Rajiv Saigal; William D. Whetstone; Geoffrey T. Manley; Sanjay S. Dhall; Jacqueline C. Bresnahan; Mervyn Maze; Xiangning Jiang; Neel S. Singhal; Michael S. Beattie; Hua Su; Zhonghui Guan

doi:10.1002/ctm2.1650

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1650 DOI: 10.1002/ctm2.1650

RESEARCH ARTICLE

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke

Author information +

¹. Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA

². Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California, USA

³. Department of Neurology, Cangzhou People's Hospital, Cangzhou, China

⁴. Department of Anesthesiology, Shandong Provincial Hospital, Shandong University, Jinan, China

⁵. Department of Anesthesiology, Qianfoshan Hospital, Shandong University, Jinan, China

⁶. Department of Anesthesiology, The Second Affiliated Hospital, Nanchang University, Nanchang, China

⁷. Department of Anesthesiology, Guangzhou Medical University, Guangzhou, China

⁸. Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China

⁹. Medical School, University of California San Francisco, San Francisco, California, USA

¹⁰. Department of Anesthesiology, No. 1 People's Hospital, Huaian, China

¹¹. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China

¹². Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA

¹³. Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California, USA

¹⁴. Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

¹⁵. Department of Neurology, Hebei Medical University, Shijiazhuang, China

¹⁶. Department of Radiology, University of California San Francisco, San Francisco, California, USA

¹⁷. Department of Orthopedic Surgery, Orthopaedic Trauma Institute, University of California San Francisco, San Francisco, California, USA

¹⁸. Department of Neurology, University of California San Francisco, San Francisco, California, USA

¹⁹. Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA

²⁰. Department of Neurosurgery, Harbor UCLA Medical Center, Torrance, California, USA

hua.su@ucsf.edu

zhonghui.guan@ucsf.edu

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Abstract

ATF3 was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively.

Serum ATF3 protein levels are elevated in clinical patients within 24 hours after SCI or ischemic stroke.

ATF3 exhibits neuroprotective properties, as evidenced by the worse neurological outcomes and larger damage regions observed in Atf3 knockout mice compared to wildtype mice following SCI or ischemic stroke.

Keywords

activating transcription factor 3 (ATF3) / biomarker / neuronal injury / neuroprotection / spinal cord injury / stroke

Cite this article

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Jonathan Z. Pan,Zhanqiang Wang,Wei Sun,Peipei Pan,Wei Li,Yongtao Sun,Shoulin Chen,Amity Lin,Wulin Tan,Liangliang He,Jacob Greene,Virginia Yao,Lijun An,Rich Liang,Qifeng Li,Jessica Yu,Lingyi Zhang,Nikolaos Kyritsis,Xuan Duong Fernandez,Sara Moncivais,Esmeralda Mendoza,Pamela Fung,Gongming Wang,Xinhuan Niu,Qihang Du,Zhaoyang Xiao,Yuwen Chang,Peiyuan Lv,J. Russell Huie,Abel Torres-Espin,Adam R. Ferguson,Debra D. Hemmerle,Jason F. Talbott,Philip R. Weinstein,Lisa U. Pascual,Vineeta Singh,Anthony M. DiGiorgio,Rajiv Saigal,William D. Whetstone,Geoffrey T. Manley,Sanjay S. Dhall,Jacqueline C. Bresnahan,Mervyn Maze,Xiangning Jiang,Neel S. Singhal,Michael S. Beattie,Hua Su,Zhonghui Guan. ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Clinical and Translational Medicine, 2024, 14(4): e1650 DOI:10.1002/ctm2.1650

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.