ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke

Jonathan Z. Pan , Zhanqiang Wang , Wei Sun , Peipei Pan , Wei Li , Yongtao Sun , Shoulin Chen , Amity Lin , Wulin Tan , Liangliang He , Jacob Greene , Virginia Yao , Lijun An , Rich Liang , Qifeng Li , Jessica Yu , Lingyi Zhang , Nikolaos Kyritsis , Xuan Duong Fernandez , Sara Moncivais , Esmeralda Mendoza , Pamela Fung , Gongming Wang , Xinhuan Niu , Qihang Du , Zhaoyang Xiao , Yuwen Chang , Peiyuan Lv , J. Russell Huie , Abel Torres-Espin , Adam R. Ferguson , Debra D. Hemmerle , Jason F. Talbott , Philip R. Weinstein , Lisa U. Pascual , Vineeta Singh , Anthony M. DiGiorgio , Rajiv Saigal , William D. Whetstone , Geoffrey T. Manley , Sanjay S. Dhall , Jacqueline C. Bresnahan , Mervyn Maze , Xiangning Jiang , Neel S. Singhal , Michael S. Beattie , Hua Su , Zhonghui Guan

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1650

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (4) : e1650 DOI: 10.1002/ctm2.1650
RESEARCH ARTICLE

ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke

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Abstract

ATF3 was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively.

Serum ATF3 protein levels are elevated in clinical patients within 24 hours after SCI or ischemic stroke.

ATF3 exhibits neuroprotective properties, as evidenced by the worse neurological outcomes and larger damage regions observed in Atf3 knockout mice compared to wildtype mice following SCI or ischemic stroke.

Keywords

activating transcription factor 3 (ATF3) / biomarker / neuronal injury / neuroprotection / spinal cord injury / stroke

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Jonathan Z. Pan,Zhanqiang Wang,Wei Sun,Peipei Pan,Wei Li,Yongtao Sun,Shoulin Chen,Amity Lin,Wulin Tan,Liangliang He,Jacob Greene,Virginia Yao,Lijun An,Rich Liang,Qifeng Li,Jessica Yu,Lingyi Zhang,Nikolaos Kyritsis,Xuan Duong Fernandez,Sara Moncivais,Esmeralda Mendoza,Pamela Fung,Gongming Wang,Xinhuan Niu,Qihang Du,Zhaoyang Xiao,Yuwen Chang,Peiyuan Lv,J. Russell Huie,Abel Torres-Espin,Adam R. Ferguson,Debra D. Hemmerle,Jason F. Talbott,Philip R. Weinstein,Lisa U. Pascual,Vineeta Singh,Anthony M. DiGiorgio,Rajiv Saigal,William D. Whetstone,Geoffrey T. Manley,Sanjay S. Dhall,Jacqueline C. Bresnahan,Mervyn Maze,Xiangning Jiang,Neel S. Singhal,Michael S. Beattie,Hua Su,Zhonghui Guan. ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Clinical and Translational Medicine, 2024, 14(4): e1650 DOI:10.1002/ctm2.1650

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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