How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?

Xiaohong Kong , Chuan-Ju Liu

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (3) : e1634

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (3) : e1634 DOI: 10.1002/ctm2.1634
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How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?

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cartilage chondrocytes / osteoarthritis / sodium channel Nav1.7 / therapeutic target

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Xiaohong Kong, Chuan-Ju Liu. How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?. Clinical and Translational Medicine, 2024, 14(3): e1634 DOI:10.1002/ctm2.1634

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Zhao YP, Liu B, Tian QY, Wei JL, Richbourgh B, Liu CJ. Progranulin protects against osteoarthritis through interacting with TNF-alpha and beta-Catenin signalling. Ann Rheum Dis. 2015;74:2244-2253.

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Fu W, Hettinghouse A, Chen Y, et al. 14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis. Ann Rheum Dis. 2021;80:1615-1627.

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Fu W, Hu W, Yi YS, et al. TNFR2/14-3-3epsilon signaling complex instructs macrophage plasticity in inflammation and autoimmunity. J Clin Invest. 2021;131:e144016.

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Fu W, Vasylyev D, Bi Y, et al. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature. 2024;625:557-565.

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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