JCAD deficiency delayed liver regenerative repair through the Hippo–YAP signalling pathway

Abstract

• JCAD deficiency leads to an impaired liver growth after PH due to cell division blockage.

• JCAD competes with LATS2 for WWC1 interaction, resulting in LATS2 inhibition, YAP activation and enhanced expression of cell cycle-associated genes.

• Delineation of JCADHippoYAP signalling pathway would facilitate to improve prognosis of acute liver failure and graft growth in living-donor liver transplantation.

Keywords

cell cycle phase visualisation / Hippo–YAP signalling pathway / JCAD / liver regeneration / WWC1

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.