Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway

Chenfeng Yuan; Hanhui Hong; Nan Wang; Tong Chen; Maosheng Cao; Yun Zhao; Caomeihui Shen; Xue Chen; Yuxin Luo; Boqi Zhang; Xu Zhou; Chunjin Li

doi:10.1002/ctm2.1603

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (3) : e1603 DOI: 10.1002/ctm2.1603

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Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway

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Chenfeng Yuan, Hanhui Hong, Nan Wang, Tong Chen, Maosheng Cao, Yun Zhao, Caomeihui Shen, Xue Chen, Yuxin Luo, Boqi Zhang, Xu Zhou, Chunjin Li. Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway. Clinical and Translational Medicine, 2024, 14(3): e1603 DOI:10.1002/ctm2.1603

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References

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[1]	Chang C, Chen YT, Yeh SD, et al. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci U S A. 2004;101:6876-6881.

[2]	Matsui H, Takahashi T. Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3. Endocrinology. 2001;142:4918-4929.

[3]	Matsui H, Moriyama A, Takahashi T. Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity. Eur J Biochem. 2000;267:6858-6865.

[4]	Båvner A, Matthews J, Sanyal S, Gustafsson JA, Treuter E. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res. 2005;33:3561-3569.

[5]	Jing J, Ding N, Wang D, et al. Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells. Cell Death Dis. 2020;11:626.

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.