Bidirectional crosstalk between cancer cells and cancer-associated fibroblasts in mixed organoid system elicits transcriptomic characteristics of pancreatic cancer with potential therapeutic vulnerabilities

Jae-Il Choi; Min Jae Yang; Kyoung-Jin Woo; So Hyun Park; Dakeun Lee; Seokhwi Kim

doi:10.1002/ctm2.1597

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (2) : e1597 DOI: 10.1002/ctm2.1597

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Bidirectional crosstalk between cancer cells and cancer-associated fibroblasts in mixed organoid system elicits transcriptomic characteristics of pancreatic cancer with potential therapeutic vulnerabilities

Jae-Il Choi ¹^,²
, Min Jae Yang ³
, Kyoung-Jin Woo ¹^,²
, So Hyun Park ¹^,²
, Dakeun Lee ¹^,²^,^†
, Seokhwi Kim ¹^,²^,^†

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Jae-Il Choi, Min Jae Yang, Kyoung-Jin Woo, So Hyun Park, Dakeun Lee, Seokhwi Kim. Bidirectional crosstalk between cancer cells and cancer-associated fibroblasts in mixed organoid system elicits transcriptomic characteristics of pancreatic cancer with potential therapeutic vulnerabilities. Clinical and Translational Medicine, 2024, 14(2): e1597 DOI:10.1002/ctm2.1597

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.