Paeonol could alleviate diabetes-related spermatogenic dysfunction via SIRT3-dependent redox rebalancing

References

[1] Sun H, Saeedi P, Karuranga S, et al. IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119.

[2] Facondo P, Di Lodovico E, Delbarba A, et al. The impact of diabetes mellitus type 1 on male fertility: systematic review and meta-analysis. Andrology. 2022;10(3):426-440.

[3] Glenn DR, McClure N, Lewis SE. The hidden impact of diabetes on male sexual dysfunction and fertility. Hum Fertil. 2003;6(4):174-179.

[4] Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T. Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum Reprod Update. 2018;24(1):86-105.

[5] Zhou C, Zhang Y, Jiao X, Wang G, Wang R, Wu Y. SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats. Reg Anesth Pain Med. 2021;46(1):49-56.

[6] Tsounapi P, Honda M, Dimitriadis F, et al. Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats. Asian J Androl. 2017;19(6):639-646.

[7] Liu J, Li X, Bai H, et al. Traditional uses, phytochemistry, pharmacology, and pharmacokinetics of the root bark of Paeonia x suffruticosa andrews: a comprehensive review. J Ethnopharmacol. 2023;308:116279.

[8] Nasiri A, Vaisi-Raygani A, Rahimi Z, Bakhtiari M, Bahrehmand F, Kiani A, et al. Evaluation of the relationship among the levels of SIRT1 and SIRT3 with oxidative stress and DNA fragmentation in asthenoteratozoospermic men. Int J Fertil Steril. 2021;15(2):135-140.

[9] Liu J, Wang S, Feng L, et al. Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. J Med Food. 2013;16(7):577-586.

[10] Defeudis G, Mazzilli R, Tenuta M, et al. Erectile dysfunction and diabetes: a melting pot of circumstances and treatments. Diabetes Metab Res Rev. 2022;38(2):e3494.

RIGHTS & PERMISSIONS

2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.