Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis

Minxiao Yi , Ye Yuan , Li Ma , Long Li , Wan Qin , Bili Wu , Bolong Zheng , Xin Liao , Guangyuan Hu , Bo Liu

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (1) : e1546

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (1) : e1546 DOI: 10.1002/ctm2.1546
RESEARCH ARTICLE

Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis

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Abstract

• Activated TGFβ1 has a superior capacity in predicting radiation pneumonitis (RP) risk and plays a vital role in the development of radiation-induced pulmonary fibrosis (RIPF).

• Conditional knock out Itgav in myofibroblasts prevented mice from developing RIPF.

• Cilengitide alleviated the development of RIPF by inhibiting αv integrinmediated TGFβ1 activation and may be used in targeted approaches for preventing RIPF.

Keywords

cilengitide / radiation-induced pulmonary fibrosis / transforming growth factor beta 1 / αv integrin

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Minxiao Yi, Ye Yuan, Li Ma, Long Li, Wan Qin, Bili Wu, Bolong Zheng, Xin Liao, Guangyuan Hu, Bo Liu. Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis. Clinical and Translational Medicine, 2024, 14(1): e1546 DOI:10.1002/ctm2.1546

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2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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