Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis
Minxiao Yi , Ye Yuan , Li Ma , Long Li , Wan Qin , Bili Wu , Bolong Zheng , Xin Liao , Guangyuan Hu , Bo Liu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (1) : e1546
Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis
• Activated TGFβ1 has a superior capacity in predicting radiation pneumonitis (RP) risk and plays a vital role in the development of radiation-induced pulmonary fibrosis (RIPF). • Conditional knock out Itgav in myofibroblasts prevented mice from developing RIPF. • Cilengitide alleviated the development of RIPF by inhibiting αv integrinmediated TGFβ1 activation and may be used in targeted approaches for preventing RIPF.
cilengitide / radiation-induced pulmonary fibrosis / transforming growth factor beta 1 / αv integrin
2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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