ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes

Abstract

• The H3K4me3 mark and chromatin accessibility at the ARID5B promoter are increased in vitro model mimicked APS.

• ARID5B-mediated LINC01128 induces pyroptosis and apoptosis via p-STAT3 by binding to BTF3.

• ARID5B is high- expressed in patients with primary APS and positively correlated with LINC01128 expression.

• OICR-9429 treatment mitigates pyroptosis and related inflammation in vivo and in vitro models mimicked APS.

Keywords

apoptosis / APS / ARID5B / epigenetics / LINC01128 / pyroptosis / thrombosis

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