ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes
Yuan Tan , Jiao Qiao , Shuo Yang , Qingchen Wang , Hongchao Liu , Qi Liu , Weimin Feng , Boxin Yang , Zhongxin Li , Liyan Cui
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (1) : e1539
ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes
• The H3K4me3 mark and chromatin accessibility at the ARID5B promoter are increased in vitro model mimicked APS. • ARID5B-mediated LINC01128 induces pyroptosis and apoptosis via p-STAT3 by binding to BTF3. • ARID5B is high- expressed in patients with primary APS and positively correlated with LINC01128 expression. • OICR-9429 treatment mitigates pyroptosis and related inflammation in vivo and in vitro models mimicked APS.
apoptosis / APS / ARID5B / epigenetics / LINC01128 / pyroptosis / thrombosis
2024 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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