Sex differences in structural cell-mediated immune regulation: Implications for precision respiratory medicine

References

[1] Bloom SI, Islam MT, Lesniewski LA, Donato AJ. Mechanisms and consequences of endothelial cell senescence. Nat Rev Cardiol. 2022;20(1):38-51.

[2] Massaro D, Massaro GD. Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice. Am J Physiol: Lung Cell Mol Physiol. 2004;287(6):L1154-1159.

[3] Qi D, He J, Wang D, et al. 17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro. Respir Res. 2014;15(1):159.

[4] Haase M, Laube M, Thome UH. Sex-specific effects of sex steroids on alveolar epithelial Na+ transport. Am J Physiol: Lung Cell Mol Physiol. 2017;312(3):L405-L414.

[5] Cephus JY, Gandhi VD, Shah R, et al. Estrogen receptor-alpha signaling increases allergen-induced IL-33 release and airway inflammation. Allergy. 2021;76(1):255-268.

[6] Trivedi S, Labuz D, Deering-Rice CE, et al. IL-33 induces NF-kappaB activation in ILC2 that can be suppressed by in vivo and ex vivo 17beta-estradiol. Front Allergy. 2022;3:1062412.

[7] Cephus JY, Stier MT, Fuseini H, et al. Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep. 2017;21(9):2487-2499.

[8] Bult L, Thelen JC, Rauh SP, JCCMit Veen, Braunstahl GJ. Dupilumab responder types and predicting factors in patients with type 2 severe asthma: a real-world cohort study. Respir Med. 2024;231:107720.

[9] Park E, Safdar Z. Pulmonary Hypertension in Women. Methodist DeBakey Cardiovasc J. 2024;20(2):70-80.

[10] Sangam S, Sun X, Schwantes-An T-H, et al. SOX17 Deficiency Mediates Pulmonary Hypertension: at the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023;207(8):1055-1069.

[11] Schroeder BA, Cuevas E, Graber JJ. Multidisciplinary tumor boards present technical and financial challenges in the COVID-19 era. Ann Oncol. 2021;32(7):839-853.

[12] Aguilar-Pineda JA, Albaghdadi M, Jiang W, et al. Structural and functional analysis of female sex hormones against SARS-CoV-2 cell entry. Int J Mol Sci. 2021;22(21):11508.

[13] Baggio C, Ramaschi GE, Oliviero F, et al. Sex-dependent PD-L1/sPD-L1 trafficking in human endothelial cells in response to inflammatory cytokines and VEGF. Biomed Pharmacother. 2023;162:114670.

[14] Kalidhindi RSR, Katragadda R, Beauchamp KL, Pabelick CM, Prakash YS, Sathish V. Androgen receptor-mediated regulation of intracellular calcium in human airway smooth muscle cells. Cell Physiol Biochem. 2019;53(1):215-228.

[15] Hu WP, Xie L, Hao SY, et al. Protective effects of progesterone on pulmonary artery smooth muscle cells stimulated with interleukin 6 via blocking the shuttling and transcriptional function of STAT3. Int Immunopharmacol. 2022;102:108379.

[16] Reddy KD, Rutting S, Tonga K, et al. Sexually dimorphic production of interleukin-6 in respiratory disease. Physiol Rep. 2020;8(11):e14459.

[17] Zhu H, Wang J, Liu Y, et al. Estrogen attenuates stiffness-driven fibrotic signaling via transcriptional regulation. Biophys J. 2025;124(12):2092-2102.

[18] Liao X, Wu D, Gao J, et al. Sex differences in immune cells: mechanistic perspectives and clinical correlates in physiology and disease. Front Immunol. 2026;17:1650527.

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2026 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.