Nemo-like kinase orchestrates the PAMP and circumstance of macrophage death in sepsis

Julia E. Steinbeck; Adil Rasheed

doi:10.1002/ctd2.70139

Clinical and Translational Discovery ›› 2026, Vol. 6 ›› Issue (2) :e70139 DOI: 10.1002/ctd2.70139

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Nemo-like kinase orchestrates the PAMP and circumstance of macrophage death in sepsis

Julia E. Steinbeck ¹
, Adil Rasheed ¹^,²

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Julia E. Steinbeck, Adil Rasheed. Nemo-like kinase orchestrates the PAMP and circumstance of macrophage death in sepsis. Clinical and Translational Discovery, 2026, 6 (2) : e70139 DOI:10.1002/ctd2.70139

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References

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[1]	Meyer NJ, Prescott HC. Sepsis and septic shock. N Engl J Med. 2024;391:2133-2146.

[2]	Beane A, Shankar-Hari M. Long-term ill health in sepsis survivors: an ignored health-care challenge?. Lancet. 2024;404:1178-1180.

[3]	Rasheed A, Rayner KJ. Macrophage responses to environmental stimuli during homeostasis and disease. Endocr Rev. 2021;42:407-435.

[4]	Pandeya A, Kanneganti TD. Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes. Trends Mol Med. 2024;30:74-88.

[5]	Newton K, Dixit VM, Kayagaki N. Dying cells fan the flames of inflammation. Science. 2021;374:1076-1080.

[6]	Xia Y, Yao RQ, Liu HF, et al. NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis. Clin Transl Med. 2026;16:e70616.

[7]	Ishitani T, Ishitani S. Nemo-like kinase, a multifaceted cell signaling regulator. Cell Signal. 2013;25:190-197.

[8]	Rayner KJ. Cell death in the vessel wall: the good, the bad, the ugly. Arterioscler Thromb Vasc Biol. 2017;37:e75-e81.

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2026 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.