A novel PRR15-TGF-β axis in decidual microenvironment dysfunction associated with advanced maternal age

Hui Luo; Ruizhi Feng; Jie zheng; Ming Zhang

doi:10.1002/ctd2.70118

Clinical and Translational Discovery ›› 2026, Vol. 6 ›› Issue (1) :e70118 DOI: 10.1002/ctd2.70118

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A novel PRR15-TGF-β axis in decidual microenvironment dysfunction associated with advanced maternal age

Hui Luo ¹^,²^,³^,⁴
, Ruizhi Feng ⁵
, Jie zheng ⁶
, Ming Zhang ¹^,²^,³^,⁴

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Hui Luo, Ruizhi Feng, Jie zheng, Ming Zhang. A novel PRR15-TGF-β axis in decidual microenvironment dysfunction associated with advanced maternal age. Clinical and Translational Discovery, 2026, 6(1): e70118 DOI:10.1002/ctd2.70118

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References

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[2]	Vento-Tormo R, Efremova M, Botting RA, et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018; 563: 347-353.

[3]	Xie H, Lu Y, Zhang A, et al. Single-cell transcriptome analyses reveal disturbed decidual microenvironment in women of advanced maternal age. Clin Transl Med. 2025; 15:e70541.

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[6]	Yang M, Ong J, Meng F, et al. Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells. Cell. 2023; 186: 4271-4288.

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2026 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.