From immune architecture to clinical decision: Insights into the TLS-based RNA model for metastatic risk in nasopharyngeal carcinoma

Ciming Sun; Biao Jiang; Kang Ning

doi:10.1002/ctd2.70097

Clinical and Translational Discovery ›› 2025, Vol. 5 ›› Issue (6) : e70097 DOI: 10.1002/ctd2.70097

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From immune architecture to clinical decision: Insights into the TLS-based RNA model for metastatic risk in nasopharyngeal carcinoma

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Ciming Sun, Biao Jiang, Kang Ning. From immune architecture to clinical decision: Insights into the TLS-based RNA model for metastatic risk in nasopharyngeal carcinoma. Clinical and Translational Discovery, 2025, 5(6): e70097 DOI:10.1002/ctd2.70097

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References

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[1]	Liu SL, Sun XS, Chen QY, et al. Development and validation of a transcriptomics-based gene signature to predict distant metastasis and guide induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma. Eur J Cancer. 2022; 163: 26-34.

[2]	Liu Y, Ye SY, He S, et al. Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma. Nat Commun. 2024; 15(1): 7713.

[3]	Lv J, Wei Y, Yin JH, et al. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment. Nat Med. 2023; 29(6): 1424-1436.

[4]	Su ZY, Siak PY, Leong CO, Cheah SC. Nasopharyngeal carcinoma and its microenvironment: past, current, and future perspectives. Front Oncol. 2022; 12:840467.

[5]	Fridman WH, Meylan M, Petitprez F, Sun CM, Italiano A, Sautès-Fridman C. B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome. Nat Rev Clin Oncol. 2022; 19(7): 441-457.

[6]	Schumacher TN, Thommen DS. Tertiary lymphoid structures in cancer. Science. 2022; 375(6576):eabf9419.

[7]	Hou Z, Feng P, Chiang CL, et al. Tertiary lymphoid structure-related RNA indicator as metastasis risk factor in nasopharyngeal carcinoma. Clin Transl Med. 2025. Unpublished manuscript.

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2025 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.