A novel mechanism for maintaining spindle normality in mammalian oocytes

Zhi-Xia Yang , Zi-Fu Wang , Dong Zhang

Clinical and Translational Discovery ›› 2025, Vol. 5 ›› Issue (5) : e70089

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Clinical and Translational Discovery ›› 2025, Vol. 5 ›› Issue (5) :e70089 DOI: 10.1002/ctd2.70089
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A novel mechanism for maintaining spindle normality in mammalian oocytes

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Zhi-Xia Yang, Zi-Fu Wang, Dong Zhang. A novel mechanism for maintaining spindle normality in mammalian oocytes. Clinical and Translational Discovery, 2025, 5(5): e70089 DOI:10.1002/ctd2.70089

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Wu T, Dong J, Fu J, et al. The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022; 378(6621):eabq7361.

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Wu T, Luo Y, Zhang M, et al. Mechanisms of minor pole-mediated spindle bipolarization in human oocytes. Science. 2024; 385(6711):eado1022.

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Feng R, Sang Q, Kuang Y, et al. Mutations in TUBB8 and human oocyte meiotic arrest. N Engl J Med. 2016; 374(3): 223-232.

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Yang P, Yin C, Li M, et al. Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects. Clin Genet. 2021; 99(1): 208-214.

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Luo H, Chen J, Li C, et al. Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition. Clin Transl Med. 2025; 15(1):e70193.

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2025 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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