The potential of NAT10-mediated ac4C acetylation in clinical translation

Xuqiao Mei; Wanxin Duan; Jiawei Hu; Shisiyu Zheng; Yuhuang Xu; Yongguang Zhang; Jianming Weng; Xiao Yang

doi:10.1002/ctd2.70061

Clinical and Translational Discovery ›› 2025, Vol. 5 ›› Issue (4) : e70061 DOI: 10.1002/ctd2.70061

EDITORIAL

The potential of NAT10-mediated ac4C acetylation in clinical translation

Author information +

History +

PDF

Cite this article

Download citation ▾

Xuqiao Mei, Wanxin Duan, Jiawei Hu, Shisiyu Zheng, Yuhuang Xu, Yongguang Zhang, Jianming Weng, Xiao Yang. The potential of NAT10-mediated ac4C acetylation in clinical translation. Clinical and Translational Discovery, 2025, 5(4): e70061 DOI:10.1002/ctd2.70061

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Roundtree IA, Evans ME, Pan T, He C. Dynamic RNA modifications in gene expression regulation. Cell. 2017; 169: 1187-1200.

[2]	Xiao B, Wu S, Tian Y, et al. Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase. Cell Biol Toxicol. 2024; 41: 17.

[3]	Arango D, Sturgill D, Alhusaini N, et al. Acetylation of cytidine in mRNA promotes translation efficiency. Cell. 2018; 175: 1872-1886.e1824.

[4]	Ding M, Yu Z, Lu T, Hu S, Zhou X, Wang X. N-acetyltransferase 10 facilitates tumorigenesis of diffuse large B-cell lymphoma by regulating AMPK/mTOR signalling through N4-acetylcytidine modification of SLC30A9. Clin Transl Med. 2024; 14:e1747.

[5]	Qu Z, Pang X, Mei Z, et al. The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. Redox Biol. 2024; 72:103145.

[6]	Liu X, Cai S, Zhang C, et al. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 2018; 46: 9601-9616.

[7]	Wang C, Ma X. The role of acetylation and deacetylation in cancer metabolism. Clin Transl Med. 2025; 15:e70145.

[8]	Wang G, Zhang M, Zhang Y, et al. NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression. Clin Transl Med. 2022; 12:e738.

[9]	Deng M, Zhang L, Zheng W, et al. Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. J Exp Clin Cancer Res. 2023; 42: 9.

[10]	Dalhat MH, Mohammed MRS, Alkhatabi HA, et al. NAT10: an RNA cytidine transferase regulates fatty acid metabolism in cancer cells. Clin Transl Med. 2022; 12:e1045.

[11]	Wu M, Wong C-M. mRNA cytidine N4-acetylation by NAT10 modulates lipid utilization in breast cancer. Clin Transl Discov. 2022; 2:e2140.

[12]	Chen M, Chen Y, Wang K, Deng X, Chen J. Non-m6A RNA modifications in haematological malignancies. Clin Transl Med. 2024; 14:e1666.

[13]	Yu C, Chen Y, Luo H, et al. NAT10 promotes vascular remodelling via mRNA ac4C acetylation. Eur Heart J. 2024; 46: 288-304.

[14]	Liu D, Kuang Y, Chen S, et al. NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis. Ann Rheum Dis. 2024; 83: 1118-1131.

[15]	Dalhat MH, Mohammed MRS, Ahmad A, Khan MI, Choudhry H. Remodelin, a N-acetyltransferase 10 (NAT10) inhibitor, alters mitochondrial lipid metabolism in cancer cells. J Cell Biochem. 2021; 122: 1936-1945.

[16]	Ma W, Tian Y, Shi L, et al. N-acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration. Nat Commun. 2024; 15: 2137.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.