Senescence as a pathogenic driver in chronic kidney disease: From cellular fate to clinical stratification

Samuel Chauvin; Ariane Coutrot; Camille Cohen

doi:10.1002/ctd2.70059

Clinical and Translational Discovery ›› 2025, Vol. 5 ›› Issue (3) : e70059 DOI: 10.1002/ctd2.70059

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Senescence as a pathogenic driver in chronic kidney disease: From cellular fate to clinical stratification

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Samuel Chauvin, Ariane Coutrot, Camille Cohen. Senescence as a pathogenic driver in chronic kidney disease: From cellular fate to clinical stratification. Clinical and Translational Discovery, 2025, 5(3): e70059 DOI:10.1002/ctd2.70059

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References

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[1]	Tanriover C, Copur S, Mutlu A, et al. Early aging and premature vascular aging in chronic kidney disease. Clin Kidney J. 2023; 16(11): 1751-1765.

[2]	Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8(9): 729-740.

[3]	Yang L, Ma L, Fu P, Nie J. Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions. Front Med. 2025;19:250-264.

[4]	O'Sullivan ED, Mylonas KJ, Xin C, et al. Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis. Sci Transl Med. 2023; 15(698):eabn0736.

[5]	Cohen C, Le Goff O, Soysouvanh F, et al. Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1. EMBO Mol Med. 2021; 13(11):e14146.

[6]	Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5: 99-118.

[7]	Mylonas KJ, O'Sullivan ED, Humphries D, et al. Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair. Sci Transl Med. 2021; 13(594):eabb0203.

[8]	McLarnon T, Watterson S, McCallion S, et al. Sendotypes predict worsening renal function in chronic kidney disease patients. Clin Transl Med. 2025; 15(4):e70279.

[9]	McHugh D, Durán I, Gil J. Senescence as a therapeutic target in cancer and age-related diseases. Nat Rev Drug Discov. 2025; 24(1): 57-71.

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2025 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.