Exosomes and machine perfusion as a therapy to improve organ transplantation

Wayne J. Hawthorne , Rajith Amaratunga , Ahmer Hameed

Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (6) : e70025

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Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (6) : e70025 DOI: 10.1002/ctd2.70025
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Exosomes and machine perfusion as a therapy to improve organ transplantation

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cell therapies / exosomes / extracellular vesicles / hypothermic machine perfusion / normothermic machine perfusion / organ preservation / static cold storage / transplantation

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Wayne J. Hawthorne, Rajith Amaratunga, Ahmer Hameed. Exosomes and machine perfusion as a therapy to improve organ transplantation. Clinical and Translational Discovery, 2024, 4(6): e70025 DOI:10.1002/ctd2.70025

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References

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CuendeN, Tullius SG, IzetaA, et al. Promoting equitable and affordable patient access to safe and effective innovations in donation and transplantation of substances of human origin and derived therapies. Transplantation. 2025;109(1):36-47.

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StimmederS, LeberB, SucherR, Stiegler P. Genetic modulation: future trends toward graft optimization during machine perfusion. Transplantation. 2024;108(3):614-624.

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BurdeyronP, GiraudS, LepoittevinM, et al. Dynamic conditioning of porcine kidney grafts with exosomes derived from urine progenitor cells: a proof-of-concept study. Clin Transl Med. 2024;14(12):e70095.

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HameedAM, LuDB, BurnsH, et al. Pharmacologic targeting of renal ischemia-reperfusion injury using a normothermic machine perfusion platform. Sci Rep. 2020;10(1):6930.

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Klein NulendR, HameedA, SinglaA, et al. Normothermic machine perfusion and normothermic regional perfusion of DCD kidneys before transplantation: a systematic review. Transplantation. Published online: July 18, 2024.

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WattsRP, ThomO, FraserJF. Inflammatory signalling associated with brain dead organ donation: from brain injury to brain stem death and posttransplant ischaemia reperfusion injury. J Transplant. 2013;2013:521369.

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LiL, WangR, JiaY, RongR, XuM, ZhuT. Exosomes derived from mesenchymal stem cells ameliorate renal ischemic-reperfusion injury through inhibiting inflammation and cell apoptosis. Front Med. 2019;6:269.

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DenguF, AbbasSH, EbelingG, Nasralla D. Normothermic machine perfusion (NMP) of the liver as a platform for therapeutic interventions during ex-vivo liver preservation: a review. J Clin Med. 2020;9(4):1046.

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RigoF, De Stefano N, Navarro-TablerosV, et al. Extracellular vesicles from human liver stem cells reduce injury in an ex vivo normothermic hypoxic rat liver perfusion model. Transplantation. 2018;102(5):e205-e10.

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HameedAM, WangZ, YoonP, et al. Normothermic ex vivo perfusion before transplantation of the kidney (next-kidney):a single-center, nonrandomized feasibility study. Transplantation. Published online: October 23, 2024.

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2024 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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