Otubain 2 promotes muramyl dipeptide-mediated anti-colitogenic effects due to de-ubiquitination of receptor interaction protein 2

Jochen Mattner

Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) : e70014

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Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) : e70014 DOI: 10.1002/ctd2.70014
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Otubain 2 promotes muramyl dipeptide-mediated anti-colitogenic effects due to de-ubiquitination of receptor interaction protein 2

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Jochen Mattner. Otubain 2 promotes muramyl dipeptide-mediated anti-colitogenic effects due to de-ubiquitination of receptor interaction protein 2. Clinical and Translational Discovery, 2024, 4(5): e70014 DOI:10.1002/ctd2.70014

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References

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DuX, XuJ, MeiF, et al. Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammation. Clin Transl Med. 2024;14:e70038.

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WatanabeT, AsanoN, MurrayPJ, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest. 2008;118:545-559.

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ShenJ, LouL, DuX, et al. YOD1 sustains NOD2-mediated protective signalling in colitis by stabilizing RIPK2. EMBO Rep. 2024.

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2024 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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