EccDNA, STING activation, and their potential roles in DLBCL prognosis and therapy

Xi-Bo Hu , Wei-Ying Wang , Xiao-Jian Sun , Qun-Ling Zhang

Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) : e70013

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Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) :e70013 DOI: 10.1002/ctd2.70013
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EccDNA, STING activation, and their potential roles in DLBCL prognosis and therapy

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cGAS / DLBCL / eccDNA / prognosis / STING / therapy

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Xi-Bo Hu, Wei-Ying Wang, Xiao-Jian Sun, Qun-Ling Zhang. EccDNA, STING activation, and their potential roles in DLBCL prognosis and therapy. Clinical and Translational Discovery, 2024, 4(5): e70013 DOI:10.1002/ctd2.70013

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WangY, WangM, DjekidelMN, et al. eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 2021;599(7884):308-314.

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DunphyG, Flannery SM, AlmineJF, et al. Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-kappaB Signaling after Nuclear DNA Damage. Mol Cell. 2018;71(5):745-760.e5.

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2024 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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