Integrating single-cell RNA sequencing data to decipher heterogeneity and function of macrophages in various organs and diseases

Xinjie Xu , Zichen Wu , Zhiwei Zeng , Jiaying Cao , Liang Chen

Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) : e70005

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Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (5) : e70005 DOI: 10.1002/ctd2.70005
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Integrating single-cell RNA sequencing data to decipher heterogeneity and function of macrophages in various organs and diseases

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single-cell RNA sequencing / integration / macrophages / heterogeneity / function

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Xinjie Xu, Zichen Wu, Zhiwei Zeng, Jiaying Cao, Liang Chen. Integrating single-cell RNA sequencing data to decipher heterogeneity and function of macrophages in various organs and diseases. Clinical and Translational Discovery, 2024, 4(5): e70005 DOI:10.1002/ctd2.70005

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References

[1]

MassE, Nimmerjahn F, KierdorfK, SchlitzerA. Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol. 2023;23:563-579.

[2]

Shapouri-MoghaddamA, Mohammadian S, VaziniH, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233:6425-6440.

[3]

MulderK, PatelAA, KongWT, et al. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease. Immunity. 2021;54:1883-1900.

[4]

ChengS, LiZ, GaoR, et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell. 2021;184:792-809.

[5]

DeczkowskaA, WeinerA, AmitI. The physiology, pathology, and potential therapeutic applications of the TREM2 signaling pathway. Cell. 2020;181:1207-1217.

[6]

HulsmansM, Schloss MJ, LeeIH, et al. Recruited macrophages elicit atrial fibrillation. Science. 2023;381:231-239.

[7]

DickSA, WongA, HamidzadaH, et al. Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles. Sci Immunol. 2022;7:eabf7777.

[8]

CaronniN, La Terza F, VittoriaFM, et al. IL-1β(+) macrophages fuel pathogenic inflammation in pancreatic cancer. Nature. 2023;623:415-422.

[9]

XuX, HuaX, MoH, HuS, SongJ. Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside. Basic Res Cardiol. 2023;118:7.

[10]

DaccacheJA, EngF, CaoL, et al. Single-cell RNA sequencing data identify a conserved population of metallothionein-expressing macrophages that may be ubiquitous in vital human organs. Clin Transl Discov. 2024;4:e348.

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2024 The Author(s). Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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