The Asymptotic Behavior of Conditional Granger Causality with Respect to Sampling Interval

Jinlong Mei , Kai Chen , Yanyang Xiao , Songting Li , Douglas Zhou

CSIAM Trans. Life Sci. ›› 2025, Vol. 1 ›› Issue (1) : 45 -66.

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CSIAM Trans. Life Sci. ›› 2025, Vol. 1 ›› Issue (1) :45 -66. DOI: 10.4208/csiam-ls.SO-2024-0003
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The Asymptotic Behavior of Conditional Granger Causality with Respect to Sampling Interval

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Abstract

Granger causality (GC) stands as a powerful causal inference tool in time series analysis. Typically estimated from time series data with finite sampling rate, the GC value inherently depends on the sampling interval τ. Intuitively, a higher data sampling rate leads to a time series that better approximates the real signal. However, previous studies have shown that the bivariate GC converges to zero linearly as τ approaches zero, which will lead to mis-inference of causality due to vanishing GC value even in the presence of causality. In this work, by performing mathematical analysis, we show this asymptotic behavior remains valid in the case of conditional GC when applying to a system composed of more than two variables. We validate the analytical result by computing GC value with multiple sampling rates for the simulated data of Hodgkin-Huxley neuronal networks and the experimental data of intracranial EEG signals. Our result demonstrates the hazard of GC inference with high sampling rate, and we propose an accurate inference approach by calculating the ratio of GC to τ as τ approaches zero.

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Causal inference / conditional Granger causality / sampling rate / asymptotic behavior / Hodgkin-Huxley model

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Jinlong Mei, Kai Chen, Yanyang Xiao, Songting Li, Douglas Zhou. The Asymptotic Behavior of Conditional Granger Causality with Respect to Sampling Interval. CSIAM Trans. Life Sci., 2025, 1(1): 45-66 DOI:10.4208/csiam-ls.SO-2024-0003

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References

[1]

L. Barnett, A. B. Barrett, and A. K. Seth, Granger causality and transfer entropy are equivalent for Gaussian variables, Phys. Rev. Lett., 103:238701, 2009.

[2]

L. Barnett and A. K. Seth, The MVGC multivariate Granger causality toolbox: A new approach to Granger-causal inference, J. Neurosci. Methods, 223:50-68, 2014.

[3]

bbrinkm sbaldassano, and W. Cukierski, UPenn and Mayo clinic’s seizure detection challenge, Kaggle, 2014. https://kaggle.com/competitions/seizure-detection

[4]

I. Bojinov and N. Shephard, Time series experiments and causal estimands: Exact randomization tests and trading, J. Amer. Statist. Assoc., 114:1665-1682, 2019.

[5]

S. L. Bressler and A. K. Seth, Wiener-Granger causality: A well established methodology, NeuroImage, 58:323-329, 2011.

[6]

S. Cekic, D. Grandjean, and O. Renaud, Multiscale Bayesian state-space model for Granger causality analysis of brain signal, J. Appl. Stat., 46:66-84, 2019.

[7]

F. Chen, J. Ke, R. Qi, Q. Xu, Y. Zhong, T. Liu, J. Li, L. Zhang, and G. Lu, Increased inhibition of the amygdala by the mPFC may reflect a resilience factor in post-traumatic stress disorder: A restingstate fMRI Granger causality analysis, Front. Psychiatry, 9:516, 2018.

[8]

H. Cheng, D. Cai, and D. Zhou, The extended Granger causality analysis for Hodgkin-Huxley neuronal models, Chaos, 30:103102, 2020.

[9]

D. Cohen and N. Tsuchiya, The effect of common signals on power, coherence and Granger causality: Theoretical review, simulations, and empirical analysis of fruit fly LFPs data, Front. Syst. Neurosci., 12:30, 2018.

[10]

A. Compte, M. V. Sanchez-Vives, D. A. McCormick, and X. J. Wang, Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model, J. Neurophysiol., 89:2707-2725, 2003.

[11]

M. Dhamala, G. Rangarajan, and M. Ding, Analyzing information flow in brain networks with nonparametric Granger causality, NeuroImage, 41:354-362, 2008.

[12]

M. Ding, Y. Chen, and S. L. Bressler, Granger causality: Basic theory and application to neuroscience,in: Handbook of Time Series Analysis: Recent Theoretical Developments and Applications, Wiley, 437-460, 2006.

[13]

M. Ding and C. Wang, Analyzing MEG data with Granger causality: Promises and pitfalls,in: Magnetoencephalography, Springer, 647-657, 2019.

[14]

K. J. Friston, Functional and effective connectivity: A review, Brain Connect., 1:13-36, 2011.

[15]

W. Gerstner and W. M. Kistler, Spiking Neuron Models: Single Neurons, Populations, Plasticity, Cambridge University Press, 2002.

[16]

J. F. Geweke, Measures of conditional linear dependence and feedback between time series, J. Amer. Statist. Assoc., 79:907-915, 1984.

[17]

J. Guo, F. Fang, W. Wang, and F. Ren, EEG emotion recognition based on Granger causality and CapsNet neural network, in: 2018 5th IEEE International Conference on Cloud Computing and Intelligence Systems (CCIS), IEEE, 47-52, 2018.

[18]

M. Hejazi and A. Motie Nasrabadi, Prediction of epilepsy seizure from multi-channel electroencephalogram by effective connectivity analysis using Granger causality and directed transfer function methods, Cogn. Neurodyn., 13:461-473, 2019.

[19]

A. L. Hodgkin and A. F. Huxley, The components of membrane conductance in the giant axon of Loligo, J. Physiol., 116:473-496, 1952.

[20]

A. L. Hodgkin and A. F. Huxley, Propagation of electrical signals along giant nerve fibres, Proc. R. Soc. Lond. B Biol. Sci., 140:177-183, 1952.

[21]

A. L. Hodgkin and A. F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol., 117:500-544, 1952.

[22]

A. L. Hodgkin, A. F. Huxley, and B. Katz, Measurement of current-voltage relations in the membrane of the giant axon of Loligo, J. Physiol., 116:424-448, 1952.

[23]

S. Li, Y. Xiao, D. Zhou, and D. Cai, Causal inference in nonlinear systems: Granger causality versus time-delayed mutual information, Phys. Rev. E, 97:052216, 2018.

[24]

C. Luo, F. Li, P. Li, C. Yi, C. Li, Q. Tao, X. Zhang, Y. Si, D. Yao, G. Yin, P. Song, H. Wang, and P. Xu, A survey of brain network analysis by electroencephalographic signals, Cogn. Neurodyn., 16:17-41, 2022.

[25]

P. Masani, The prediction theory of multivariate stochastic processes, III, Acta Math., 104:141-162, 1960.

[26]

J. R. McCrorie and M. J. Chambers, Granger causality and the sampling of economic processes, J. Econometrics, 132:311-336, 2006.

[27]

A. V. Rangan and D. Cai, Fast numerical methods for simulating large-scale integrate-and-fire neuronal networks, J. Comput. Neurosci., 22:81-100, 2007.

[28]

P. Rangarajan and R. P. N. Rao, Estimation of vector autoregressive parameters and Granger causality from noisy multichannel data, IEEE Trans. Biomed. Eng., 66:2231-2240, 2019.

[29]

H. P. Robinson and N. Kawai, Injection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons, J. Neurosci. Methods, 49:157-165, 1993.

[30]

D. J. A. Smit, C. J. Stam, D. Posthuma, D. I. Boomsma, and E. J. C. De Geus, Heritability of “small-world” networks in the brain: A graph theoretical analysis of resting-state EEG functional connectivity, Hum. Brain Mapp., 29:1368-1378, 2008.

[31]

V. Solo, State-space analysis of Granger-Geweke causality measures with application to fMRI, Neural Comput., 28:914-949, 2016.

[32]

Y. Sun, D. Zhou, A. V. Rangan, and D. Cai, Pseudo-Lyapunov exponents and predictability of Hodgkin-Huxley neuronal network dynamics, J. Comput. Neurosci., 28:247-266, 2010.

[33]

Z.-q. K. Tian, K. Chen, S. Li, D. W. McLaughlin, and D. Zhou, Quantitative relations among causality measures with applications to pulse-output nonlinear network reconstruction, bioRxiv:2023.04.02.535284, 2023.

[34]

P. P. Vaidyanathan, The Theory of Linear Prediction, in: Synthesis Lectures on Signal Processing, Springer, 2008.

[35]

M. P. van den Heuvel and H. E. Hulshoff Pol, Exploring the brain network: A review on restingstate fMRI functional connectivity, Eur. Neuropsychopharmacol., 20:519-534, 2010.

[36]

X. Wen, G. Rangarajan, and M. Ding, Multivariate Granger causality: An estimation framework based on factorization of the spectral density matrix, Philos. Trans. Roy. Soc. A, 371:20110610, 2013.

[37]

X.-T. Wen, X.-J. Zhao, L. Yao, and X. Wu, Applications of Granger causality model to connectivity network based on fMRI time series, in: Advances in Natural Computation. ICNC 2006. Lecture Notes in Computer Science, Springer, 4221:205-213, 2006.

[38]

N. Wiener and P. Masani, The prediction theory of multivariate stochastic processes, Acta Math., 98:111-150, 1957.

[39]

N. Wiener and P. Masani, The prediction theory of multivariate stochastic processes, II: The linear predictor, Acta Math., 99:93-137, 1958.

[40]

G. T. Wilson, The factorization of matricial spectral densities, SIAM J. Appl. Math., 23:420-426, 1972.

[41]

C. Zhang, Q.-H. Lin, C.-Y. Zhang, Y.-G. Hao, X.-F. Gong, F. Cong, and V. D. Calhoun, Comparison of functional network connectivity and Granger causality for resting state fMRI data, in: Advances in Neural Networks - ISNN 2017, Springer, 559-566, 2017.

[42]

D. Zhou, Y. Xiao, Y. Zhang, Z. Xu, and D. Cai, Causal and structural connectivity of pulse-coupled nonlinear networks, Phys. Rev. Lett., 111:54102, 2013.

[43]

D. Zhou, Y. Xiao, Y. Zhang, Z. Xu, and D. Cai, Granger causality network reconstruction of conductance-based integrate-and-fire neuronal systems, PLoS ONE, 9(2):e87636, 2014.

[44]

D. Zhou, Y. Zhang, Y. Xiao, and D. Cai, Analysis of sampling artifacts on the Granger causality analysis for topology extraction of neuronal dynamics, Front. Comput. Neurosci., 8:75, 2014.

[45]

D. Zhou, Y. Zhang, Y. Xiao, and D. Cai, Reliability of the Granger causality inference, New J. Phys., 16:043016, 2014.

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