As an emerging field, gas therapy attracts increasing attention because of its distinguishing features in disease treatment. However, to achieve a therapeutic effect, the concentration of gas should be carefully controlled. Thus, a suitable and convenient technology is required to monitor the gas concentration in vivo. Besides, the transportation of gas into human body and in vivo biodistribution of gas also need to be evaluated. Among the technologies adopted in gas therapy, fluorescence imaging technology is the first choice due to its high specificity, high sensitivity, and non-invasion. And as the core of fluorescence imaging, the properties of fluorescent dyes directly determine the quality of imaging. So, it is critical to choose suitable gas probes for different purposes. Here, we review common gas detection methods, including a brief introduction of fluorescence, the distinctive properties of five fluorophore cores, and the detection mechanisms of common gas probes. Then, the applications of gas probes in gas delivery, gas release, and gas therapy are summarized. At last, we discuss the potential of developing further intelligent gas probes and fluorescence imaging technologies for gas therapy.

Asymmetric tetrahedral carbon is the basic structural unit of many organic compounds in life and its molecular chirality plays a key role in regulating biological functions. Silica (SiO₂) is highly earth abundant and its basic unit is also the tetrahedral form of SiO₄. However, much less attention has been paid to the molecular-scale chirality of SiO₂ frameworks with repeating SiO₄ units because it is challenging to enantioselectively control the molecular structures of SiO₂. Research into the chiral molecular structures of SiO₂ deserves to be a significant topic for understanding widespread chiral phenomena and for exploring the chiral properties hidden in inorganic matter. This review highlights the asymmetric synthesis strategies that endow SiO₂ with chirality transferred from asymmetric carbon at the molecular scale. The chirality transfer ability of SiO₂ is also demonstrated for the construction of various inorganic and/or organic chiral materials with a wide range of applications in asymmetric synthesis, circularly polarized luminescence and Raman scattering-based chiral recognition.