Model study on photoinduced direct activation of cyclohexane for carbonylation reaction

Abstract

C(sp³)–H bond activation is widely recognized as a key area for the development of organic chemistry in the 21st century. However, its activation has long been a challenge for scientists. The advent of photochemistry has offered hope for addressing this challenge. Various radicals generated under light irradiation have emerged as versatile hydrogen atom transfer (HAT) agents, streamlining the C–H activation process while enabling excellent regioselectivity. Herein, we present a chlorine radical-mediated hydrogen atom abstraction approach conducted under pressurized carbon monoxide (40 bar), which successfully achieves the C–H bond activation and carbonylation of cyclohexane.

Keywords

Alkane / carbonylation / radical / amide / photochemistry

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