Schizophrenic behavior of 2,3-oxidosqualene sterol cyclase from pig liver towards 2,3-oxidosqualene analogs

Abstract

We report the unusual behavior of oxidosqualene sterol cyclase from pig liver towards 2,3-oxidosqualene analogs bearing two alkyl groups different from a methyl, at their Δ^18-19 double bond: unambiguous structure determinations of the products and tentative rational for their formation are described.

Keywords

Biosynthesis / multistep hemi-synthesis of natural product analogs / performance liquid chromatography / structure determination

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