Technical Specification for Hemocompatibility Assessment of Human Mesenchymal Stem Cells

Jialing Liu; Weiyang Liang; Wenjie Xia; Ping Wang; Jie Hao; Tao Na; Sunxing Yan; Yu Zhang; Ka Li; Qiyuan Li; Guangjin Pan; Jun Wei; Qubo Chen; Jiani Cao; Peijun Zhai; Boqiang Fu; Hengjun Gao; Yong Zhang; Lei Wang; Meimei Guo; Shijun Hu; Lijun Zhu; Yang Zhao; Weiqi Zhang; Zhihong Wu; Yifang Ping; Hongling Zhao; Shuaishuai Niu; Tongbiao Zhao; Aijin Ma; Andy Peng Xiang; Xiaoyong Chen

doi:10.1111/cpr.70183

Cell Proliferation ›› 2026, Vol. 59 ›› Issue (4) :e70183 DOI: 10.1111/cpr.70183

EDITORIAL

Technical Specification for Hemocompatibility Assessment of Human Mesenchymal Stem Cells

Jialing Liu ¹
, Weiyang Liang ²
, Wenjie Xia ³
, Ping Wang ⁴
, Jie Hao ⁵^,⁶
, Tao Na ⁶^,⁷
, Sunxing Yan ⁸
, Yu Zhang ⁶^,⁹
, Ka Li ⁶^,¹⁰
, Qiyuan Li ⁶^,¹¹
, Guangjin Pan ⁶^,¹²
, Jun Wei ⁶^,¹³
, Qubo Chen ⁶^,¹⁴
, Jiani Cao ⁶^,⁹
, Peijun Zhai ⁶^,¹⁵
, Boqiang Fu ⁶^,¹⁶
, Hengjun Gao ⁶^,¹⁷
, Yong Zhang ⁶^,¹⁸
, Lei Wang ⁵^,⁶
, Meimei Guo ¹⁹
, Shijun Hu ⁶^,²⁰
, Lijun Zhu ⁶^,²¹
, Yang Zhao ⁶^,²²
, Weiqi Zhang ⁶^,²³
, Zhihong Wu ⁶^,²⁴
, Yifang Ping ⁶^,²⁵
, Hongling Zhao ⁶^,²⁶
, Shuaishuai Niu ⁵^,⁶
, Tongbiao Zhao ⁶^,²⁶
, Aijin Ma ⁶^,²⁷
, Andy Peng Xiang ¹^,⁶
, Xiaoyong Chen ¹

Author information +

¹. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China

². NMPA Key Laboratory for Quality Control of Blood Products, Guangdong Institute for Drug Control, Guangzhou, China

³. Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, China

⁴. Shenzhen Institute for Drug Control, Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen, China

⁵. National Stem Cell Resource Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

⁶. Standard Committee, Chinese Society for Cell Biology, Shanghai, China

⁷. National Institutes for Food and Drug Control, Beijing, China

⁸. Guangzhou Cellgenes Biotechnology Co., Ltd., Guangzhou, China

⁹. Zephyrm Biotechnologies Co., Ltd, Beijing, China

¹⁰. Zhongshan Hospital, Fudan University, Shanghai, China

¹¹. Shenzhen Medical Academy of Research and Translation, Shenzhen, China

¹². Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

¹³. General Hospital of Ningxia Medical University, Ningxia, China

¹⁴. State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

¹⁵. China National Accreditation Service for Conformity Assessment (CNAS), Beijing, China

¹⁶. National Institute of Metrology, Beijing, China

¹⁷. National Engineering Center for Biochip at Shanghai, Shanghai, China

¹⁸. Shenzhen HHLIFE Co., Ltd., Shenzhen, China

¹⁹. Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China

²⁰. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Medical College, Soochow University, Suzhou, China

²¹. Institute of Scientific and Technical Information of China, Beijing, China

²². Peking University, China

²³. China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

²⁴. Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

²⁵. Army Military Medical University, Chongqing, China

²⁶. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China

²⁷. Beijing Technology and Business University, Beijing, China

tbzhao@ioz.ac.cn

maaj@btbu.edu.cn

xiangp@mail.sysu.edu.cn

chenxiaoy@mail.sysu.edu.cn

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Abstract

‘Technical specification for haemocompatibility assessment of human mesenchymal stem cells’ is the first set of guidelines on haemocompatibility assessment of human mesenchymal stem cells (MSCs) in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard outlines the methods for assessing the hemocompatibility of human mesenchymal stem cells and specifies the requirements for the selection of evaluation indicators, calculation of indicator values, and determination of hemocompatibility levels. It is applicable for evaluating the hemocompatibility of MSCs prior to their contact with blood. This guideline was originally released by the Chinese Society for Cell Biology on October 28, 2024. We anticipate that the publication of this specification will promote the institutional adoption, acceptance, and execution of proper testing protocols, thereby accelerating the international standardization of MSCs for clinical development and therapeutic applications.

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Jialing Liu, Weiyang Liang, Wenjie Xia, Ping Wang, Jie Hao, Tao Na, Sunxing Yan, Yu Zhang, Ka Li, Qiyuan Li, Guangjin Pan, Jun Wei, Qubo Chen, Jiani Cao, Peijun Zhai, Boqiang Fu, Hengjun Gao, Yong Zhang, Lei Wang, Meimei Guo, Shijun Hu, Lijun Zhu, Yang Zhao, Weiqi Zhang, Zhihong Wu, Yifang Ping, Hongling Zhao, Shuaishuai Niu, Tongbiao Zhao, Aijin Ma, Andy Peng Xiang, Xiaoyong Chen. Technical Specification for Hemocompatibility Assessment of Human Mesenchymal Stem Cells. Cell Proliferation, 2026, 59 (4) : e70183 DOI:10.1111/cpr.70183